Larry.Winger@ncl.ac.uk


PROFESSIONAL ACTIVITIES

Current Research Projects:

Immunometric assays for small molecules, incorporating anti-idiotypic technology to identify hapten-occupied binding sites on capture antibody.

High-Performance Assays of Small Molecules: Enhanced Sensitivity, Rapidity, and Convenience Demonstrated with a Noncompetitive Immunometric Anti-Immune Complex Assay System for Digoxin. Self, C.H., Dessi, J.L. and Winger, L.A. (1994) Clinical Chemistry 40:2035-2041.

Novel developments in immunoassay. Self, C.H., Dessi, J.L., Winger, L.A. (1994) Proc. UK NEQAS Meeting 1:171-175.

Ultra-specific immunoassays for small molecules: roles of wash steps and multiple binding formats. Self, C.H., Dessi, J.L. and Winger, L.A. (1996) Clinical Chemistry 42:1527-1531.

Enhanced specificity for small molecules in a convenient format which removes a limitation of competitive immunoassay. Winger, L.A., Dessi, J.L. and Self, C.H. (1996) J. Immunological Methods 199:185-191.

 

Journal Impact Factors as reported by ISI, catalogued by topic or by Journal alphabetically.


Other Projects

We have been interested in the general phenomenon of human T cell activation by OKT3 antibody, particularly in the effect of (Fab')2 and Fab fragments of this antibody, in the presence or absence of macrophages.

 


Research Projects of the Past

1969 - Present

Skin-graft rejection in earthworms

Kinetics of PHA stimulation of human lymphocytes

Sequential proliferation of T cells after mitogen stimulation

Induction of antibody-forming cells from human PBL in vitro

Immortalisation of human antibody-forming cells by EBV transformation

Identification of zygote-specific determinants of malaria

Consideration of altruistic vaccine in malaria

Identification of liver-stage specific determinants of malaria

Consideration of models of MHC Class I associated liver-stage determinants/vaccines

Models of cerebral malaria

Identification of malaria-infected mosquitos by MAb to circumsporozoite antigen

Generation of monoclonal antibodies to a variety of natural and recombinant proteins

 


Note: don't confuse me with another R.W. Winger, who with colleagues has some really neat antibody-antigen interactions pictures available for viewing.

 


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