Change in Free Energy

Note that, with or without the enzyme the initial and final energy levels are the same and G is the same, i.e. the thermodynamics of the reaction are unchanged.

The enzyme has increased the rate by taking the reaction through a new path and thereby lowering the activation energy (). Since is lower, more of the substrate (A) will reach the transition state (B*), i.e. the transition state is stabilized. This in turn leads to the formation of more product (C).

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