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How Penicillin Kills Bacteria



610K '.mov' file


Penicillin kills bacteria by interfering with the ability to synthesize cell wall. In this sequence, Escherichia coli were incubated in penicillin for 30 minutes. The bacteria lengthen, but cannot divide. Eventually the weak cell wall ruptures (last panel). To learn more about how penicillin works be sure to check out " What the Heck is Penicillin" at Jack's "Bugs in the News".

Antibiotic use selects for populations of antibiotic-resistant pathogens. Some bacteria avoid the effect of penicillin by the production of penicillinase, an enzyme that destroys penicillin. For more information on how bacteria such as Staph aureus become resistant to penicillin and vancomycin see the excellent Food and Drug Administration (FDA) site "The Rise of Antibiotic-Resistant Infections".

 

 

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