Beta-Oxidation of Fatty Acids (odd chain)

View the 2-D version of this pathway.
The MDL Chemscape
CHIME plug-in
Download it for free.

Manipulate the molecules with your mouse:
  • Left-click and hold, to rotate about the X and Y axes
  • <SHIFT> + Left-click and hold, to zoom in or out
  • <SHIFT> + Right-click and hold, to rotate about the Z axis
  • <CTRL> + Right-click and hold, to translate on the X and Y axes
  • Right-click, to bring up the control menu for the molecule

It should be noted, that all odd chain fatty acids can be oxidized using the same enzymes for even chain fatty acid beta-oxidation. However, unlike even chain fatty acids, odd chain fatty acids will yield ((n-3)/2) Acetyl-CoA and one three carbon acid, Propionyl-CoA, where n is the number of carbons in the odd chain fatty acid. Propionyl-CoA, is then further broken down using the pathway shown below.


COHNP
Propionyl-CoA (3:0)
(S)-D-Methylmalonyl-CoA
(R)-L-Methylmalonyl-CoA
Succinyl-CoA

[The Metabolic Pathways of Biochemistry] - [Copyright © 1998 Karl J. Miller.]